Human Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1) Protein
208€ (10 µg)
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935106861
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name
Human Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652446
tested applications
WB, SDS-PAGE
Description
Human Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aldehyde Dehydrogenase 1 Family, Member B1 (ALDH1B1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 59 kDa Observed MW (SDS-PAGE): 59 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg18-Ser517 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30837 |
| Gene ID | 219 |
| OMIM | 100670 |
| Alias | ALDH1B1,ALDH5,ALDHX |
| Background | Protein ALDH1B1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ALDH1B1 is a mitochondrial enzyme that participates in the detoxification of aldehydes and the oxidation of acetaldehyde to acetate, a key step in ethanol metabolism. It is highly expressed in the liver, colon, and gastrointestinal tract, where it protects against oxidative stress and aldehyde-induced cellular damage. ALDH1B1 has been linked to alcohol metabolism, and its dysregulation contributes to alcohol-induced liver injury, cirrhosis, and colorectal cancer. In cancers, ALDH1B1 expression is often elevated, particularly in colorectal and pancreatic tumors, where it promotes tumorigenesis by maintaining cellular redox balance and enhancing proliferation. It also contributes to cancer stem-like properties, facilitating chemoresistance and tumor progression. Studies suggest ALDH1B1 as a promising biomarker and therapeutic target in gastrointestinal cancers and alcohol-associated diseases. Its role in mitochondrial aldehyde metabolism also links it to energy homeostasis and metabolic regulation.
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