Human Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) Protein

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
Human Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) Protein
234€ (10 µg)

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Name
Human Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx650624
Tested Applications
WB, SDS-PAGE

Description

Human ALDH1A2 Protein is a recombinant Human protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Met1-Ser422
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 49.8 kDa  Observed MW (SDS-PAGE): 50 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
O94788
Alias
RALDH 2,RalDH2,Retinaldehyde specific dehydrogenase type 2
Background
Protein ALDH1A2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

ALDH1A2, like ALDH1A1, catalyzes the conversion of retinaldehyde to retinoic acid, a critical molecule for regulating gene expression during embryonic development and organogenesis. ALDH1A2 is highly expressed during early development, particularly in tissues forming the heart, lungs, and nervous system, where it regulates retinoic acid signaling pathways essential for proper patterning and differentiation. Loss-of-function mutations in ALDH1A2 lead to congenital disorders, including congenital diaphragmatic hernia, cardiac anomalies, and craniofacial defects, due to disrupted retinoic acid gradients during development. In adults, ALDH1A2 plays a role in maintaining tissue homeostasis and regulating inflammatory responses. Its dysregulation has been linked to metabolic disorders, such as obesity and insulin resistance, as well as fibrotic diseases. ALDH1A2 is also studied in cancer biology for its role in tumor growth suppression through retinoic acid-mediated differentiation and cell cycle control.

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