Human Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) Protein
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Description
Human ALDH1A2 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 49.8 kDa Observed MW (SDS-PAGE): 50 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ser422 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94788 |
| Alias | RALDH 2,RalDH2,Retinaldehyde specific dehydrogenase type 2 |
| Background | Protein ALDH1A2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ALDH1A2, like ALDH1A1, catalyzes the conversion of retinaldehyde to retinoic acid, a critical molecule for regulating gene expression during embryonic development and organogenesis. ALDH1A2 is highly expressed during early development, particularly in tissues forming the heart, lungs, and nervous system, where it regulates retinoic acid signaling pathways essential for proper patterning and differentiation. Loss-of-function mutations in ALDH1A2 lead to congenital disorders, including congenital diaphragmatic hernia, cardiac anomalies, and craniofacial defects, due to disrupted retinoic acid gradients during development. In adults, ALDH1A2 plays a role in maintaining tissue homeostasis and regulating inflammatory responses. Its dysregulation has been linked to metabolic disorders, such as obesity and insulin resistance, as well as fibrotic diseases. ALDH1A2 is also studied in cancer biology for its role in tumor growth suppression through retinoic acid-mediated differentiation and cell cycle control.
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