Human Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) CLIA Kit
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Description
Human Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.625 ng/ml - 40 ng/ml |
| Sensitivity | < 0.215 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | RALDH 2,RalDH2,Retinaldehyde specific dehydrogenase type 2 |
| Background | CLIA Kits ALDH1A2 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALDH1A2, like ALDH1A1, catalyzes the conversion of retinaldehyde to retinoic acid, a critical molecule for regulating gene expression during embryonic development and organogenesis. ALDH1A2 is highly expressed during early development, particularly in tissues forming the heart, lungs, and nervous system, where it regulates retinoic acid signaling pathways essential for proper patterning and differentiation. Loss-of-function mutations in ALDH1A2 lead to congenital disorders, including congenital diaphragmatic hernia, cardiac anomalies, and craniofacial defects, due to disrupted retinoic acid gradients during development. In adults, ALDH1A2 plays a role in maintaining tissue homeostasis and regulating inflammatory responses. Its dysregulation has been linked to metabolic disorders, such as obesity and insulin resistance, as well as fibrotic diseases. ALDH1A2 is also studied in cancer biology for its role in tumor growth suppression through retinoic acid-mediated differentiation and cell cycle control.
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