Human Adrenocorticotropic Hormone Receptor (MC2R) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for MC2R
proveedor
Abbexareference
abx392236Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Adrenocorticotropic Hormone Receptor (MC2R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Adrenocorticotropic hormone receptor (MC2R) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
MC2R, also known as the adrenocorticotropic hormone receptor, is a G protein-coupled receptor specifically activated by adrenocorticotropic hormone (ACTH). MC2R is primarily expressed in the adrenal cortex, where it regulates the synthesis and release of glucocorticoids, such as cortisol, in response to ACTH binding. Upon activation, MC2R couples to Gs proteins, stimulating adenylyl cyclase and increasing cAMP levels, which activate protein kinase A (PKA). This signaling cascade drives steroidogenesis by upregulating key enzymes involved in cortisol production. MC2R is essential for maintaining the hypothalamic-pituitary-adrenal (HPA) axis, which controls the body’s response to stress, inflammation, and metabolism. Dysregulation of MC2R signaling is linked to conditions such as Addison’s disease (adrenal insufficiency), Cushing’s syndrome (excess cortisol), and ACTH resistance syndromes. Mutations in MC2R can impair cortisol production, leading to glucocorticoid deficiencies. Targeting MC2R and ACTH pathways offers therapeutic opportunities for managing adrenal disorders and inflammatory conditions involving glucocorticoid regulation.
Características del producto
category
ELISA Kits
immunogen target
Adrenocorticotropic Hormone Receptor (MC2R)
reactivity
Human
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 34 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
MC2R,ACTHR,melanocortin 2 receptor,adrenocorticotropic hormone receptor,melanocortin 2 receptor (adrenocorticotropic hormone)
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
MC2R
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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