Human Adenylate Kinase Isoenzyme 5 (AK5) Protein
234€ (2 µg)
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Name
Human Adenylate Kinase Isoenzyme 5 (AK5) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073860
Tested Applications
SDS-PAGE
Description
Human Adenylate Kinase 5 Protein is a recombinant protein kinase expressed in E.coli. The protein consists of a single, non-glycosylated polypeptide chain containing 586 amino acids (1-562 AA) and is fused to a His tag at the N-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Adenylate Kinase IsoProtein 5 (AK5) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: 1-562 AA Tag: N-terminal His tag |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Observed MW | 65.9 kDa |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques.<br> Sterile Filtered. |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl, pH 8.0, containing 20% Glycerol and 1 mM DTT. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y6K8 |
| Alias | AK6 |
| Background | Protein AK5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Concentration: 0.25 mg/ml |
Background
AK5 is a cytosolic adenylate kinase predominantly expressed in the brain, where it plays a role in neural energy metabolism and synaptic function. Unlike other AK isoforms, AK5 demonstrates substrate specificity for ATP/GTP and AMP. It is thought to regulate energy transfer and storage in neurons, particularly in response to neurotransmission demands. AK5 expression correlates with cognitive functions, and its dysfunction has been implicated in neurodevelopmental disorders and memory deficits. AK5 has been shown to influence energy-sensing pathways, such as AMPK, thereby contributing to neuronal survival during energy depletion.
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