Human ADAM10 Protein
234€ (2 µg)
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name
Human ADAM10 Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx262305
tested applications
SDS-PAGE
Description
ADAM10 Protein is a recombinant protein produced in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ADAM10 |
| Host | E. coli |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 55.1 kDa Sequence Fragment: Thr 214-672 Glu Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM Tris (pH 8), 1mM EDTA and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | O14672 |
| Alias | MADM, HsT18717,Kuz ,CD156d,AD10,AD18,RAK,KUZ,ADAM-10 |
| Background | Protein ADAM10 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADAM10, also known as ADAM metallopeptidase domain 10, is a type I transmembrane glycoprotein belonging to the ADAM (a disintegrin and metalloproteinase) family of proteins. It is encoded by the ADAM10 gene located on human chromosome 15. ADAM10 plays crucial roles in various biological processes, including cell adhesion, cell fusion, cell signaling, proteolysis, and ectodomain shedding of membrane proteins. It is involved in the cleavage of a wide range of cell surface proteins, including cytokines, growth factors, adhesion molecules, and receptors. ( Notch receptors, amyloid precursor protein (APP), cadherins, and several cytokines and growth factors). The proteolytic activity of ADAM10 is tightly regulated, as its dysregulation can have significant implications in various diseases, including cancer, Alzheimer's disease, inflammation, and cardiovascular diseases. ADAM10-mediated cleavage of Notch receptors is crucial for various developmental processes, and dysregulation of this process has been implicated in cancer and neurodegenerative diseases. ADAM10 has gained significant attention as a potential therapeutic target for various diseases due to its involvement in critical cellular processes and its ability to modulate the activity of numerous substrates. Inhibition or modulation of ADAM10 activity is being explored as a strategy for the treatment of diseases such as cancer, Alzheimer's disease, and inflammatory disorders
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