Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2 (ADAMTS2) ELISA Kit

Product specifications

ELISA Kits

ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2 (ADAMTS2)

Human

Colorimetric

Quantitative

Sandwich

78 pg/ml - 5000 pg/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

O95450

PCINP,NPI,ADAM-TS2,Procollagen N-Endopeptidase,ADAMTS-2

Elisa kits for ADAMTS2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ADAMTS2, also known as A Disintegrin And Metalloproteinase with Thrombospondin Motifs 2, is another member of the ADAMTS protein family ADAMTS2, like other members of the ADAMTS family, contains multiple domains including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. ADAMTS2 is primarily known for its role in collagen processing and extracellular matrix remodeling. It specifically cleaves procollagen molecules, which are precursors to collagen, at specific sites to produce mature collagen molecules. This process is crucial for the proper assembly and organization of collagen fibers in various tissues, including skin, bone, and cartilage. Mutations in the ADAMTS2 gene have been linked to a rare genetic disorder called Ehlers-Danlos syndrome type VIIC (EDS VIIC), also known as dermatosparaxis type EDS. EDS VIIC is characterized by severe skin fragility, joint laxity, and easy bruising due to abnormal collagen processing and structure. These mutations disrupt the enzymatic activity of ADAMTS2, leading to impaired collagen processing and the characteristic symptoms of the disorder.Studies on ADAMTS2 and its role in collagen processing have implications for understanding the pathogenesis of connective tissue disorders like Ehlers-Danlos syndrome and for developing potential therapeutic approaches. Research efforts are focused on elucidating the molecular mechanisms underlying ADAMTS2 function and its regulation in collagen metabolism.

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