Human Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Protein

Este producto es parte de ACADL - Acyl-CoA Dehydrogenase Long Chain
Human Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein ACADL

proveedor

Abbexa

reference

abx650415

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ACADL Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ACADL , also known as long-chain acyl-CoA dehydrogenase (LCAD), is a mitochondrial enzyme critical for the β-oxidation of long-chain fatty acids. It catalyzes the first step in the oxidative breakdown of long-chain fatty acyl-CoAs, facilitating their conversion into energy through the tricarboxylic acid (TCA) cycle and electron transport chain. ACADL is predominantly expressed in energy-demanding tissues such as the liver, heart, and skeletal muscle, where fatty acid metabolism is essential for maintaining energy homeostasis during fasting and sustained physical activity. Dysregulation or mutations in the ACADL gene can result in long-chain acyl-CoA dehydrogenase deficiency, a rare metabolic disorder characterized by hypoglycemia, muscle weakness, and lipid accumulation due to impaired fatty acid oxidation. ACADL also plays a role in lipid signaling and mitochondrial health, contributing to cellular responses to metabolic stress. Its enzymatic activity underscores its importance in energy metabolism, lipid regulation, and mitochondrial function, making it a key target for studies on metabolic diseases and energy balance.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Acyl Coenzyme A Dehydrogenase, Long Chain (ACADL)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 28.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile214-Lys430 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ACADL


dry ice

No


availability

Shipped within 5-7 working days.


alias

ACAD4,LCAD


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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