Human Acyl-CoA synthetase family member 3, mitochondrial (ACSF3) ELISA Kit

Este producto es parte de ACSF - Acyl-CoA Synthetase Family Member
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Acyl-CoA synthetase family member 3, mitochondrial (ACSF3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500873
tested applications
ELISA

Description

Human Acyl-CoA synthetase family member 3, mitochondrial (ACSF3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Acyl-CoA synthetase family member 3, mitochondrial (ACSF3) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryELISA Kits
Immunogen TargetAcyl-CoA synthetase family member 3, mitochondrial (ACSF3)
ReactivityHuman
Detection MethodColorimetric
Assay DataQuantitative
Test Range0.156 ng/ml - 10 ng/ml
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
Size 196 tests
FormLyophilized
Tested ApplicationsELISA
Sample TypeTissue homogenates, cell lysates and other biological fluids.
AvailabilityShipped within 5-15 working days. The validity for this kit is 6 months.
StorageShipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry IceNo
UniProt IDQ4G176
AliasACSF3
BackgroundElisa kits for ACSF3
StatusRUO
NoteValidity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ACSF3 is a mitochondrial acyl-CoA synthetase responsible for the activation of malonic and methylmalonic acids, essential steps in the metabolism of certain fatty acids and amino acids. Its primary function is to facilitate the incorporation of these intermediates into metabolic pathways such as the tricarboxylic acid (TCA) cycle and gluconeogenesis. ACSF3 is highly expressed in the liver and skeletal muscle, where it supports energy homeostasis and metabolic flexibility by processing odd-chain fatty acids and branched-chain amino acids. Mutations in the ACSF3 gene are associated with combined malonic and methylmalonic aciduria, a rare metabolic disorder characterized by the accumulation of malonic acid and methylmalonic acid, leading to metabolic acidosis and developmental delays. By regulating these metabolic intermediates, ACSF3 plays a crucial role in preventing the buildup of toxic metabolites and ensuring efficient energy production under metabolic stress conditions.

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