Human Activity Dependent Neuroprotector Protein (ADNP) ELISA Kit

Este producto es parte de ADNP - Activity dependent neuroprotector homeobox protein
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643.5€ (96 tests)

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935106861
info@markelab.com
name
Human Activity Dependent Neuroprotector Protein (ADNP) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx150572
tested applications
ELISA

Description

Human Activity Dependent Neuroprotector Protein (ADNP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ADNP concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of ADNP (ADNP)

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Activity Dependent Neuroprotector Protein (ADNP)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.06 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
ADNP, ADNP1, KIAA0784,HVDAS, MRD28
Background
Elisa kits for ADNP
Status
RUO
Note
Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Activity-dependent neuroprotector homeobox protein (ADNP) is a transcription factor and neuroprotective protein essential for brain development, neurogenesis, and chromatin remodeling through interactions with SWI/SNF chromatin-remodeling complexes It regulates gene expression critical for maintaining neuronal survival, synaptic plasticity, and cognitive processes Mutations or deletions in ADNP cause ADNP syndrome (Helsmoortel-Van der Aa syndrome), a neurodevelopmental disorder marked by intellectual disability, autism spectrum disorder traits, motor dysfunction, and developmental delay ADNP is also linked to neurodegenerative diseases, including Alzheimer’s disease, where it modulates tau phosphorylation, amyloid toxicity, and neuronal resilience Dysregulation of ADNP disrupts cell cycle control, proliferation, and apoptosis pathways, leading to impaired neuronal health and cognitive decline ADNP’s broad involvement in transcriptional regulation, synaptic maintenance, and neuroprotection underscores its essential role in brain function, making it a potential therapeutic target for neurodevelopmental and neurodegenerative diseases

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