Human Actin, Alpha Cardiac Muscle 1 (ACTC1) ELISA Kit
715€ (96 tests)
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name
Human Actin, Alpha Cardiac Muscle 1 (ACTC1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500913
tested applications
ELISA
Description
Human Actin, Alpha Cardiac Muscle 1 (ACTC1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Actin, Alpha Cardiac Muscle 1 (ACTC1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Actin, Alpha Cardiac Muscle 1 (ACTC1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P68032 |
| Gene ID | 70 |
| Alias | ACTC ASD5,CMD1R,CMH11,LVNC4 |
| Background | Elisa kits for ACTC1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACTC1 encodes for actin alpha 1, a protein that is a crucial component of the contractile apparatus in cardiac muscle cells (cardiomyocytes). It is a major component of the contractile apparatus in cardiac muscle cells, contributing to the contraction and relaxation of the heart. It forms filamentous structures that, along with other proteins such as myosin, tropomyosin, and troponin, make up the sarcomeres—the basic contractile units of cardiac muscle. The contraction of cardiac muscle is regulated by calcium-dependent signaling pathways that modulate the interaction between actin and myosin. During each heartbeat, calcium ions bind to troponin, leading to conformational changes that expose binding sites on actin, allowing myosin to interact and generate force for muscle contraction. The expression of ACTC1 is highly regulated during cardiac development and in response to physiological and pathological stimuli. Mutations in the ACTC1 gene have been associated with various congenital heart diseases, such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), which are characterized by abnormalities in cardiac muscle structure and function
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