Human Actin Alpha 1, Cardiac Muscle (ACTC1) Protein
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Description
Human Actin Alpha 1, Cardiac Muscle (ACTC1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Actin Alpha 1, Cardiac Muscle (ACTC1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 27.5 kDa Observed MW (SDS-PAGE): 29 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp156-Gly368 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P68032 |
| Gene ID | 70 |
| OMIM | 102540 |
| Alias | ACTC ASD5,CMD1R,CMH11,LVNC4 |
| Background | Protein ACTC1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ACTC1 encodes for actin alpha 1, a protein that is a crucial component of the contractile apparatus in cardiac muscle cells (cardiomyocytes). It is a major component of the contractile apparatus in cardiac muscle cells, contributing to the contraction and relaxation of the heart. It forms filamentous structures that, along with other proteins such as myosin, tropomyosin, and troponin, make up the sarcomeres—the basic contractile units of cardiac muscle. The contraction of cardiac muscle is regulated by calcium-dependent signaling pathways that modulate the interaction between actin and myosin. During each heartbeat, calcium ions bind to troponin, leading to conformational changes that expose binding sites on actin, allowing myosin to interact and generate force for muscle contraction. The expression of ACTC1 is highly regulated during cardiac development and in response to physiological and pathological stimuli. Mutations in the ACTC1 gene have been associated with various congenital heart diseases, such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), which are characterized by abnormalities in cardiac muscle structure and function
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