Human Aconitase 1 (ACO1) CLIA Kit
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Description
Human Aconitase 1 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.
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Product specifications
| Category | CLIA Kits |
| Immunogen Target | Aconitase 1 (ACO1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.625 ng/ml - 40 ng/ml |
| Sensitivity | < 0.267 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IRP1,ACONS,HEL60,IREB1,IREBP,IREBP1 |
| Background | CLIA Kits ACO1 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Aconitase 1 (ACO1) is a dual-function iron-sulfur protein located in the cytoplasm, acting as both an enzyme and an iron-responsive element-binding protein (IRP1). As an enzyme, ACO1 catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid (TCA) cycle, contributing to cellular energy production. Under low iron conditions, ACO1 switches to its role as IRP1, binding to iron-responsive elements (IREs) in mRNAs to regulate the expression of genes involved in iron metabolism, such as ferritin and transferrin receptor. This functional versatility allows ACO1 to coordinate cellular energy metabolism and iron homeostasis. Dysregulation of ACO1 is implicated in disorders related to iron overload or deficiency, as well as oxidative stress-induced damage in neurodegenerative diseases.
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ACO1 antibody
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
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