Human Acetyl Coenzyme A Acetyltransferase 1 (ACAT1) Protein
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935106861
info@markelab.com
Precio
234€ (5 µg)
Protein ACAT1
proveedor
Abbexareference
abx073370Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Acetyl-Corecombinant enzyme A acetyltransferase 1 is a recombinant enzyme.
Background
ACAT1, also known as mitochondrial acetoacetyl-CoA thiolase, is an enzyme localized in the mitochondria that catalyzes the reversible conversion of two molecules of acetyl-CoA into acetoacetyl-CoA, a critical step in ketone body synthesis and cholesterol metabolism. It is involved in energy production during periods of fasting or carbohydrate restriction by contributing to ketogenesis. ACAT1 also plays a role in the breakdown of branched-chain amino acids, linking it to amino acid metabolism. Dysregulation or mutations in the ACAT1 gene have been implicated in rare metabolic disorders such as beta-ketothiolase deficiency, which is characterized by the inability to properly metabolize ketogenic amino acids and fatty acids, leading to metabolic acidosis. Recent studies have also suggested a potential role for ACAT1 in cancer metabolism, where its activity is linked to metabolic reprogramming in tumor cells.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Acetyl CoProtein A Acetyltransferase 1 (ACAT1)
host
E. coli
form
Liquid
tested applications
SDS-PAGE
size 1
5 µg
size 2
20 µg
size 3
1 mg
observerd MW
Molecular Weight: 43.8 kDa Concentration: 1 mg/ml Sequence Fragment: 34-427 AA Tag: N-terminal His tag
expression
Recombinant
purity
> 95% (SDS-PAGE)
purification
Purified by proprietary chromatographic techniques.
recommended dilution
Optimal dilutions/concentrations should be determined by the end user.
buffer
20 mM Tris-HCl buffer (pH 7.5), 0.1M NaCl, 10% glycerol and 1 mM DTT.
storage
Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
or code
ACAT1
dry ice
No
availability
Shipped within 5-10 working days.
alias
ACAT,MAT,T2,THIL,Acetoacetyl-CoA thiolase
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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