Human ABL1(Tyrosine-protein kinase ABL1) ELISA Kit
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Product specifications
| Category | ELISA Kits |
| Reactivity | human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 31.25-2000pg/ml |
| Size 1 | 96T |
| Sample Type | Serum,Plasma,Tissue homogenates,Other biological fluids |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 6 months |
| UniProt ID | P00519 |
| Alias | ABL,BCR-ABL,CHDSKM,ABL proto-oncogene 1 non-receptor tyrosine kinase |
| Background | Elisa Kits ABL1 |
| Status | RUO |
ABL1 is a non-receptor tyrosine kinase involved in various cellular processes, including cytoskeletal remodeling, cell migration, DNA damage response, and signal transduction. It is ubiquitously expressed and localized in both the nucleus and cytoplasm, where it interacts with numerous signaling proteins. ABL1 contains SH2 and SH3 domains, a kinase domain, and regulatory regions that facilitate its interaction with other proteins and its activation in response to cellular stimuli. Dysregulation of ABL1, particularly through chromosomal translocations such as the Philadelphia chromosome, results in the BCR-ABL1 fusion protein, which drives chronic myeloid leukemia (CML) by promoting uncontrolled cell proliferation and survival. Targeting ABL1 with tyrosine kinase inhibitors, such as imatinib, has revolutionized the treatment of CML and highlighted its role as a key therapeutic target. Beyond cancer, ABL1 contributes to cellular responses to oxidative stress, DNA damage repair, and cytoskeletal dynamics, underscoring its importance in maintaining cellular homeostasis and responding to environmental challenges.
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ABL1 (pY204) Antibody is a Rabbit Polyclonal antibody against ABL1 (pY204). The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
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