Human A Disintegrin And Metalloprotease 9 (ADAM9) Protein
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Description
Recombinant ADAM9 is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | A Disintegrin And Metalloprotease 9 (ADAM9) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 27.3 kDa Observed MW (SDS-PAGE): 27 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro440-Gly680 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13443 |
| Alias | MDC9,MCMP,KIAA0021 ,CORD9,Meltrin Gamma |
| Background | Protein ADAM9 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADAM metallopeptidase domain 9 (ADAM9) is another member of the ADAM family of proteins, sharing structural similarities and functional properties with ADAM8. Like other ADAM proteins, ADAM9 contains several domains, including a metalloprotease domain, a disintegrin domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. These domains enable ADAM9 to interact with other proteins and participate in various cellular processes.ADAM9 is widely expressed in various tissues and cell types, including the brain, heart, lungs, kidneys, and reproductive organs. Its expression pattern suggests diverse roles in physiological processes.ADAM9 plays a role in cell adhesion and migration by interacting with extracellular matrix components and cell surface receptors. It can promote cell migration by cleaving adhesion molecules and releasing cell-to-cell or cell-to-matrix contacts. As a metalloprotease, ADAM9 has the ability to cleave and process various substrates, including growth factors, cytokines, cell surface receptors, and extracellular matrix proteins. This proteolytic activity allows ADAM9 to regulate signaling pathways, cell behavior, and tissue remodeling. ADAM9 is often upregulated in various cancers, including breast cancer, lung cancer, prostate cancer, and pancreatic cancer. Its overexpression is associated with tumor progression, invasion, metastasis, and angiogenesis. ADAM9 promotes cancer cell migration and invasion by cleaving extracellular matrix proteins and cell adhesion molecules.ADAM9 has been implicated in neurological disorders such as Alzheimer's disease and multiple sclerosis. Its expression in the brain suggests potential roles in synaptic plasticity, neuronal migration, and myelination.ADAM9 has also been linked to cardiovascular diseases such as atherosclerosis and cardiac remodeling. Its involvement in cell adhesion, migration, and proteolysis may contribute to vascular remodeling and plaque formation
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