Human A Disintegrin And Metalloprotease 12 (ADAM12) Protein

Product specifications

Proteins and Peptides

A Disintegrin And Metalloprotease 12 (ADAM12)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 31.3 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser513-His767
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

MLTN, MCMPMltna, Meltrin-Alpha,CAR10,MLTNA,ADAM-12

Protein ADAM12

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ADAM12, also known as ADAM metallopeptidase domain 12, is another member of the ADAM (a disintegrin and metalloproteinase) family of proteins. Like ADAM10, it is a type I transmembrane glycoprotein encoded by the ADAM12 gene. ADAM12 is known to be involved in various biological processes, including cell adhesion, migration, proliferation, proteolysis, and signaling. It has been implicated in several pathological conditions, including cancer, inflammation, and developmental disorders. ADAM12 is its involved in extracellular matrix (ECM) remodeling. It can cleave ECM components such as fibronectin and type IV collagen, thereby facilitating tissue remodeling processes like wound healing and tissue repair. Additionally, ADAM12 has been shown to interact with integrins, which are cell surface receptors involved in cell adhesion and signaling, further implicating its role in cell-ECM interactions. ADAM 12, a metalloprotease that binds insulin growth factor binding protein-3 (IGFBP-3), appears to be an effective early Down syndrome marker. Decreased levels of ADAM 12 may be detected in cases of trisomy 21. In cancer, ADAM12 expression levels have been found to be dysregulated in various tumor types, and its overexpression has been associated with tumor progression, invasion, and metastasis. It can promote cancer cell migration and invasion by cleaving ECM components, modulating cell adhesion, and facilitating epithelial-to-mesenchymal transition (EMT), a process implicated in cancer metastasis.

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