Human 14-3-3 Sigma (SFN) Protein
1235€ (100 µg)
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Name
Human 14-3-3 Sigma (SFN) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx693795
Tested Applications
SDS-PAGE
Description
Human 14-3-3 sigma Protein is a recombinant protein from Human produced in E. coli. A DNA sequence encoding the human SFN (NP_006133.1) (Met 1-Ser 248) was expressed, with two additional amino acids (Gly & Pro) at the N-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | 14-3-3 Sigma (SFN) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Ser248 |
| Origin | Human |
| Observed MW | 28 kDa |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 150mM NaCl, 10mM GSH, 25% glycerol, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_006133.1 |
| Alias | SFN, YWHAS, Stratifin,14-3-3σ protein |
| Background | Protein SFN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Stratifin (SFN) , also known as 14-3-3 sigma, is a member of the 14-3-3 protein family that acts as a critical regulator of cell cycle progression, DNA damage response, and cellular stress. It binds to phosphorylated serine/threonine residues on target proteins, facilitating their localization, stability, and activity. Stratifin is specifically involved in G2/M cell cycle checkpoint control by sequestering cyclin-dependent kinase complexes like CDC25C in the cytoplasm, preventing premature mitotic entry under DNA damage conditions. It is highly expressed in epithelial tissues and is essential for maintaining epithelial cell integrity, polarity, and stress responses. Stratifin acts as a tumor suppressor by inhibiting uncontrolled proliferation; its downregulation has been observed in breast, lung, and gastrointestinal cancers due to epigenetic silencing. Functional studies reveal its role in mediating stress-induced growth arrest and apoptosis, underscoring its importance in tumor suppression, DNA repair, and cell cycle regulation.
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