Human 14-3-3 Protein Epsilon (YWHAE) Protein
429€ (20 µg)
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935106861
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name
Human 14-3-3 Protein Epsilon (YWHAE) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693106
tested applications
SDS-PAGE
Description
Human 14-3-3 epsilon Protein is a recombinant protein from Human produced in E. coli. A DNA sequence encoding the human YWHAE (NP_006752.1) (Met 1-Gln 255) was fused with the GST tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 14-3-3 Protein Epsilon (YWHAE) |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 56 kDa Sequence Fragment: Met1-Gln255 Tag: N-terminal GST tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 150mM NaCl, 0.25mM DTT, 25% glycerol, 0.5mM GSH, pH 7.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_006752.1 |
| Alias | YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS,14-3-3 epsilon |
| Background | Protein YWHAE |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
YWHAE, another member of the 14-3-3 family, functions as an adaptor protein that regulates protein-protein interactions, cellular localization, and stability of signaling molecules. By binding to phosphorylated targets, YWHAE modulates pathways such as MAPK, Wnt/β-catenin, and PI3K/Akt, controlling processes like cell proliferation, apoptosis, and cytoskeletal dynamics. It is highly expressed in neuronal tissues, where it plays critical roles in brain development, axon guidance, and synaptic function. YWHAE also regulates the DNA damage response and tumor suppression pathways by interacting with proteins like p53 and Chk1. Dysregulation of YWHAE is linked to developmental disorders, including Miller-Dieker syndrome and neurodevelopmental abnormalities, as well as cancers where it promotes tumor progression and metastasis. Knockout models exhibit defects in brain development, impaired cell migration, and increased susceptibility to stress, emphasizing its role in neurodevelopment, cell signaling, and maintaining cellular integrity.
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