Human 14-3-3 Protein Epsilon (YWHAE) Protein
234€ (5 µg)
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Name
Human 14-3-3 Protein Epsilon (YWHAE) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073592
Tested Applications
SDS-PAGE
Description
Tyr-3/Trp-5 Monooxygenase Activation Protein, Epsilon Protein is a recombinant protein kinase.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | 14-3-3 Protein Epsilon (YWHAE) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: 1-255 AA |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Observed MW | 29 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl, pH 7.5. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 1 week. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P62258 |
| Alias | YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS,14-3-3 epsilon |
| Background | Protein YWHAE |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Concentration: 1 mg/ml |
Background
YWHAE, another member of the 14-3-3 family, functions as an adaptor protein that regulates protein-protein interactions, cellular localization, and stability of signaling molecules. By binding to phosphorylated targets, YWHAE modulates pathways such as MAPK, Wnt/β-catenin, and PI3K/Akt, controlling processes like cell proliferation, apoptosis, and cytoskeletal dynamics. It is highly expressed in neuronal tissues, where it plays critical roles in brain development, axon guidance, and synaptic function. YWHAE also regulates the DNA damage response and tumor suppression pathways by interacting with proteins like p53 and Chk1. Dysregulation of YWHAE is linked to developmental disorders, including Miller-Dieker syndrome and neurodevelopmental abnormalities, as well as cancers where it promotes tumor progression and metastasis. Knockout models exhibit defects in brain development, impaired cell migration, and increased susceptibility to stress, emphasizing its role in neurodevelopment, cell signaling, and maintaining cellular integrity.
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