935106861
info@markelab.com
Precio
687.5€ (96 tests)
Human 14-3-3 protein epsilon (YWHAE) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Tyrosine 3/Tryptophan 5 Monooxygenase Activation Protein Epsilon (YWHAe) concentrations in tissue homogenates, cell lysates and other biological fluids.
YWHAE, another member of the 14-3-3 family, functions as an adaptor protein that regulates protein-protein interactions, cellular localization, and stability of signaling molecules. By binding to phosphorylated targets, YWHAE modulates pathways such as MAPK, Wnt/β-catenin, and PI3K/Akt, controlling processes like cell proliferation, apoptosis, and cytoskeletal dynamics. It is highly expressed in neuronal tissues, where it plays critical roles in brain development, axon guidance, and synaptic function. YWHAE also regulates the DNA damage response and tumor suppression pathways by interacting with proteins like p53 and Chk1. Dysregulation of YWHAE is linked to developmental disorders, including Miller-Dieker syndrome and neurodevelopmental abnormalities, as well as cancers where it promotes tumor progression and metastasis. Knockout models exhibit defects in brain development, impaired cell migration, and increased susceptibility to stress, emphasizing its role in neurodevelopment, cell signaling, and maintaining cellular integrity.
ELISA Kits
14-3-3 protein epsilon (YWHAE)
Human
0.156 ng/ml - 10 ng/ml
< 0.06 ng/ml
Sandwich
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
5 × 96 tests
10 × 96 tests
YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS,14-3-3 epsilon
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
YWHAE
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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