Horse Tumor Necrosis Factor (TNF) Protein
proveedor
Abbexareference
abx166395Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Tumor Necrosis Factor Protein is a recombinant Horse protein expressed in E. coli.
Background
Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.
Características del producto
category
Proteins and Peptides
origin
Horse
host
E. coli
immunogen target
Tumor Necrosis Factor (TNF)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
1 mg
size 5
5 mg
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TNF
dry ice
No
availability
Shipped within 5-7 working days.
alias
TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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