Homeobox Protein NANOG (NANOG) Antibody
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Description
NANOG Antibody is a Rabbit Polyclonal antibody against NANOG. NANOG (Nanog homeobox) is a protein-coding gene. Diseases associated with NANOG include ovarian germ cell tumor, and sacrococcygeal teratoma. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Homeobox Protein NANOG (NANOG) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H9S0 |
| Gene ID | 79923 |
| NCBI Accession | NP_079141.2 |
| Background | Antibody anti-NANOG |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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NANOG antibody
Transcription regulator involved in inner cell mass and embryonic stem(ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating(ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.
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