Homeobox protein aristaless-like 4 (ALX4) Antibody (Biotin)
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Description
Homeobox protein aristaless-like 4 (ALX4) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human ALX4.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Homeobox protein aristaless-like 4 (ALX4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H161 |
| Gene ID | 60529 |
| Alias | CRS5,FND2 |
| Background | Antibody anti-ALX4 |
| Status | RUO |
Descripción
ALX4 is a homeobox transcription factor critical for skeletal development, limb formation, and hair follicle regulation. ALX4 is highly expressed in mesenchymal progenitor cells during embryonic development, where it regulates the formation of cranial bones, limbs, and other skeletal structures. Mutations in ALX4 are associated with parietal foramina, a congenital condition characterized by defects in skull ossification, as well as alopecia and hair pattern abnormalities. ALX4 functions by coordinating signaling pathways such as Wnt and BMP, which control mesenchymal differentiation, osteoblast activity, and hair follicle cycling. Loss of ALX4 function can lead to delayed skull closure, limb malformations, and impaired bone mineralization. ALX4 is also implicated in tumor suppression, as its downregulation has been observed in cancers where mesenchymal regulation is disrupted. Its role in skeletal and hair follicle development underscores its importance as a key regulator of mesenchymal differentiation and morphogenesis.
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This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2) ; an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del (11) (p11p12), causes Potocki-Shaffer syndrome (PSS) ; a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq].
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