Homeobox protein aristaless-like 4 (ALX4) Antibody
169€ (20 µg)
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Name
Homeobox protein aristaless-like 4 (ALX4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx349339
Tested Applications
ELISA, WB
Description
Homeobox protein aristaless-like 4 (ALX4) Antibody is a Rabbit Polyclonal antibody for the detection of Human, Rat ALX4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Homeobox protein aristaless-like 4 (ALX4) Immunogen: Recombinant Human Homeobox protein aristaless-like 4 protein (112-216 AA) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H161 |
| Gene ID | 60529 |
| Alias | CRS5,FND2 |
| Background | Antibody anti-ALX4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALX4 is a homeobox transcription factor critical for skeletal development, limb formation, and hair follicle regulation. ALX4 is highly expressed in mesenchymal progenitor cells during embryonic development, where it regulates the formation of cranial bones, limbs, and other skeletal structures. Mutations in ALX4 are associated with parietal foramina, a congenital condition characterized by defects in skull ossification, as well as alopecia and hair pattern abnormalities. ALX4 functions by coordinating signaling pathways such as Wnt and BMP, which control mesenchymal differentiation, osteoblast activity, and hair follicle cycling. Loss of ALX4 function can lead to delayed skull closure, limb malformations, and impaired bone mineralization. ALX4 is also implicated in tumor suppression, as its downregulation has been observed in cancers where mesenchymal regulation is disrupted. Its role in skeletal and hair follicle development underscores its importance as a key regulator of mesenchymal differentiation and morphogenesis.
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