HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody
Pida mas información
935106861
info@markelab.com
Precio
416€ (200 µl)
Antibody anti-CD74
proveedor
Abbexareference
abx432479Tested Applications
P-ELISA, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
CD74 Antibody is a Goat Polyclonal antibody against CD74.
Background
CD74, also known as the invariant chain (Ii), is a type II transmembrane glycoprotein that plays a critical role in the immune system, particularly in antigen processing and presentation. CD74 is encoded by the CD74 gene and is primarily expressed on antigen-presenting cells (APCs) such as B cells, dendritic cells, and macrophages, although it is also found on some non-immune cells, including certain epithelial and cancer cells. One of its central functions is to act as a chaperone for major histocompatibility complex class II (MHC-II) molecules, ensuring the proper folding, trafficking, and peptide loading of MHC-II, which is essential for the presentation of antigens to CD4+ T cells. In addition to its role in antigen presentation, CD74 also functions as a receptor for macrophage migration inhibitory factor (MIF), which modulates inflammatory responses and cell survival pathways.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
HLA Class II Histocompatibility Antigen Gamma Chain (CD74)
host
Goat
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
P-ELISA, IHC
purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
recommended dilution
P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user.
buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
size 1
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
CD74
dry ice
No
availability
Shipped within 5-10 working days.
alias
p33,CLIP,DHLAG,HLADG,Ia-GAMMA,HLA class II histocompatibility antigen gamma chain,HLA-DR antigens-associated invariant chain,Ia antigen-associated invariant chain (Ii)
NCBI accession
NP_001020330.1, NP_004346.1
note
Concentration: 0.5 mg/ml -
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