HLA Class I Histocompatibility Antigen, C Alpha Chain (HLA-C) Antibody
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Description
HLA Class I Histocompatibility Antigen, C Alpha Chain (HLA-C) Antibody is a Rabbit polyclonal antibody for the detection of Human HLA Class I Histocompatibility Antigen, C Alpha Chain (HLA-C).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | HLA Class I Histocompatibility Antigen, C Alpha Chain (HLA-C) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10321 |
| Gene ID | 3107 |
| NCBI Accession | NP_002108.4 |
| Background | Antibody anti-HLA-C |
| Status | RUO |
Descripción
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HLA class I histocompatibility antigen, C alpha chain (HLA-C) Antibody
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.
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