HLA class I histocompatibility antigen, A alpha chain (HLA-A) Antibody
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Description
HLA class I histocompatibility antigen, A alpha chain (HLA-A) Antibody is a monoclonal Mouse antibody for the detection of HLA-A.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | HLA class I histocompatibility antigen, A alpha chain (HLA-A) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | Q712 |
| Purity | > 95% |
| Purification | Purified by Protein G affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, FCM |
| Buffer | 0.01M PBS, pH 7.4, containing 0.05% proclin 300, 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1-2 weeks. For long-term storage, aliquot and store at -20 °C or -80 °C. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04439, P01889, P10321 |
| Background | Antibody anti-HLA-A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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HLA-A antibody
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
Ver ProductoHLA-A antibody
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
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