Histone Cell Cycle Regulator (HIRA) Antibody
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Description
Histone Cell Cycle Regulator (HIRA) Antibody is a Rabbit Polyclonal antibody against Histone Cell Cycle Regulator (HIRA).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Histone Cell Cycle Regulator (HIRA) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54198 |
| Gene ID | 7290 |
| Background | Antibody anti-HIRA |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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Histone Cell Cycle Regulator (HIRA) Antibody
HIRA Antibody is a Rabbit Polyclonal Antibody against HIRA.
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Histone Cell Cycle Regulator (HIRA) Antibody
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
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Histone Cell Cycle Regulator (HIRA) Antibody
HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
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