High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1) Antibody
494€ (250 µg)
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935106861
info@markelab.com
name
High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx415305
tested applications
IHC, FCM
Description
High Affinity Immunoglobulin Gamma Fc Receptor I (CD64) Antibody is a Rat Monoclonal antibody against High Affinity Immunoglobulin Gamma Fc Receptor I (CD64).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1) |
| Host | Rat |
| Reactivity | Mouse |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified |
| Size 1 | 250 µg |
| Form | Liquid |
| Tested Applications | IHC, FCM |
| Buffer | Tris-buffered saline. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P26151 |
| Gene ID | 14129 |
| Alias | CD64,FCG1,FCRI,CD64A,FCGR1,IGFR1,FcgammaRI,High affinity immunoglobulin gamma Fc receptor I,IgG Fc receptor I,Fc-gamma RIA |
| Background | Antibody anti-FCGR1A |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
FCGR1A (Fc gamma receptor Ia), also known as CD64, is a high-affinity receptor for the Fc region of immunoglobulin G (IgG) antibodies. It plays a crucial role in immune responses by binding to the Fc portion of IgG, mediating various immune functions such as phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and immune complex clearance. FCGR1A is predominantly expressed on monocytes, macrophages, and dendritic cells, as well as on neutrophils during inflammatory responses. The interaction between FCGR1A and IgG antibodies bridges innate and adaptive immunity, facilitating the elimination of pathogens and other foreign particles. It is also critical in the regulation of immune responses by modulating inflammatory signals. FCGR1A is involved in the recognition of opsonized particles, initiating signaling cascades that result in cytokine production, phagocytosis, and the clearance of immune complexes.
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