Receptor Tyrosine-Protein Kinase ErbB-2 Phospho-Tyr1248 (ERBB2 pY1248) Cell ELISA Kit
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Description
HER2 (pY1248) Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Receptor Tyrosine-Protein Kinase ErbB-2 Phospho-Tyr1248 (ERBB2 pY1248) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Fluorometric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 192 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P04626 |
| Gene ID | 2064 |
| OMIM | 137800 |
| Background | Elisa Kits for: ERBB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
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This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
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