Hepatocyte nuclear factor 4-alpha (HNF4A) Antibody
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Description
Hepatocyte nuclear factor 4-alpha (HNF4A) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human, Rat HNF4A.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Hepatocyte nuclear factor 4-alpha (HNF4A) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, FCM: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41235 |
| Alias | TCF,HNF4,MODY,FRTS4,MODY1,NR2A1,TCF14,HNF4a7,HNF4a8,HNF4a9,NR2A21,TCF-14,HNF4alpha,Transcription factor HNF-4,Nuclear receptor subfamily 2 group A member 1 |
| Background | Antibody anti-HNF4A |
| Status | RUO |
Descripción
Hepatocyte nuclear factor 4 alpha (HNF4A) is a critical transcription factor that plays a key role in regulating liver function, metabolism, and the development of the gastrointestinal tract HNF4A is highly expressed in the liver, where it controls the expression of genes involved in hepatic glucose production, lipid metabolism, and bile acid synthesis It also regulates the development and differentiation of liver cells and contributes to maintaining liver homeostasis HNF4A is involved in controlling genes responsible for the metabolism of steroids, carbohydrates, and lipids, and it is crucial for maintaining the liver's metabolic functions Dysregulation of HNF4A has been associated with metabolic diseases, such as diabetes, non-alcoholic fatty liver disease (NAFLD), and liver cirrhosis In addition, mutations in the HNF4A gene can lead to maturity-onset diabetes of the young (MODY), a form of diabetes characterized by early-onset, autosomal dominant inheritance of insulin resistance
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