Heparin Cofactor 2 (SERPIND1) Antibody
260€ (100 µl)
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935106861
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name
Heparin Cofactor 2 (SERPIND1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx101871
tested applications
WB, IHC
Description
Polyclonal Antibody to Heparin Cofactor 2 (SERPIND1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Heparin Cofactor 2 (SERPIND1) Immunogen: SERPIND1 (Asp276-Ser499) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05546 |
| Alias | HC2,LS2,HCF2,HCII,HLS2,THPH10,D22S673,Heparin cofactor 2,Heparin cofactor II,Protease inhibitor leuserpin-2,Serpin D1 |
| Background | Antibody anti-SERPIND1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
SERPIND1 encodes Heparin Cofactor II (HCII), a serine protease inhibitor (serpin) that plays a critical role in the regulation of coagulation. It shares functional similarities with antithrombin (SERPINC1), particularly in inhibiting thrombin, a key enzyme in the coagulation cascade. However, HCII exhibits a more specialized function as its activity is highly dependent on heparin-like glycosaminoglycans (GAGs), particularly dermatan sulfate, and to a lesser extent, heparin. HCII's involvement in thrombin inhibition and its activation through GAGs have made it an essential component in controlling clot formation and preventing thrombosis, particularly in vascular tissue. HCII deficiency has been linked to a predisposition for thromboembolic disorders and cardiovascular diseases.
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