Heparanase (HPSE) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Heparanase Antibody is a Rabbit Polyclonal antibody against Heparanase.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Heparanase (HPSE) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y251 |
| Gene ID | 10855 |
| NCBI Accession | NP_001092010.1, NM_001098540.2 |
| OMIM | 604724 |
| Background | Antibody anti-HPSE |
| Status | RUO |
Descripción
Related Products
HPSE antibody
Endoglycosidase that cleaves heparan sulfate proteoglycans(HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix(ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix(ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
Ver Producto
Inactive Heparanase 2 (HPSE2) Antibody
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti-cancer therapies.
Ver Producto
Human Heparanase (HPSE) ELISA Kit
Human Heparanase (HPSE) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Heparanase (HPA) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.. This assay has high sensitivity and excellent specificity for detection of Heparanase (HPA)
Ver Producto