Hematopoietic Progenitor Cell Antigen CD34 (CD34) Antibody (Biotin)
364€ (0.1 mg)
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Name
Hematopoietic Progenitor Cell Antigen CD34 (CD34) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139251
Tested Applications
WB, IHC, IF/ICC, FCM
Description
CD34 Antibody is a Mouse Monoclonal against CD34.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Hematopoietic Progenitor Cell Antigen CD34 (CD34) Immunogen: Permanent Human cell line derived from peripheral leucocytes of a patient suffering from chronic myeloid leukaemia. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Validated in IHC-P and ICC. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Biotin |
| Isotype | IgG1 |
| Clone ID | E334 |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IHC, IF/ICC, FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P28906 |
| Gene ID | 947 |
| Alias | Hematopoietic progenitor cell antigen CD34 |
| Background | Antibody anti-CD34 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD34 is a well-known cell surface glycoprotein that is primarily expressed on hematopoietic stem and progenitor cells (HSPCs), as well as on endothelial cells, and is used as a marker to identify early stem cells within the bone marrow and other tissues. This molecule has become an invaluable tool in both research and clinical medicine, particularly in the isolation and characterization of hematopoietic stem cells for bone marrow transplantation, and in the study of angiogenesis due to its presence on vascular endothelium. The CD34 protein belongs to the family of sialomucin-like adhesion molecules. Initially, it was identified as a marker on hematopoietic progenitor cells and subsequently found to be involved in various physiological processes, such as cell adhesion, cell signaling, and migration. CD34 is a highly glycosylated protein, and its extensive post-translational modifications, including sialylation and O-glycosylation, play important roles in its function, particularly in regulating cell-cell interactions and hematopoietic cell homing.