HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Antibody
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Description
HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Antibody is a Rabbit Polyclonal antibody against HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified |
| Size 1 | 50 µg |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7Z6Z7 |
| Background | Antibody anti-HUWE1 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
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HUWE1 antibody
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta(POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.
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