Guinea pig Transforming Growth Factor Beta 1 (TGFb1) Protein

Este producto es parte de TGFB1 - Transforming Growth Factor Beta 1
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377€ (50 µg)

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935106861
info@markelab.com
name
Guinea pig Transforming Growth Factor Beta 1 (TGFb1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069423
tested applications
WB, SDS-PAGE

Description

Recombinant Transforming Growth Factor Beta 1 (TGFb1) is a recombinant Guinea pig protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryProteins and Peptides
Immunogen TargetTransforming Growth Factor Beta 1 (TGFb1)
HostE. coli
OriginGuinea pig
ConjugationUnconjugated
Observed MWMolecular Weight: Calculated MW: 18.5 kDa Observed MW (SDS-PAGE): 21 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly279-Ser390 Tag: N-terminal His tag
ExpressionRecombinant
Purity> 95%
Size 150 µg
Size 2100 µg
Size 3200 µg
Size 4500 µg
Size 51 mg
FormLyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested ApplicationsWB, SDS-PAGE
BufferPrior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
AvailabilityShipped within 5-7 working days.
StorageStore at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDQ9Z1Y6
AliasCED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta
BackgroundProtein TGFB1
StatusRUO
NoteThis product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.

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