Guinea pig MMP-8(Matrix Metalloproteinase 8) ELISA Kit
proveedor
FineTestreference
EGP0035Tested Applications
reactivity
guinea pigstatus
RUOclonality
Background
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Matrix metalloproteinase-8 (MMP-8), also referred to as PMNL collagenase (MNL-CL), is an enzyme that cleaves collagen found in the connective tissue of most mammals. In humans, the MMP-8 protein is encoded by the MMP8 gene. Its substrates encompass collagen types I, II, III, VII, VIII, X, as well as aggrecan and gelatin. Notably, MMP-8 can undergo proteolytic activation by enzymes like stromelysin-1 (MMP-3), stromelysin-2 (MMP-10), and matrilysin-1 (MMP-7).
Background
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La metaloproteinasa de matriz-8 (MMP-8), también conocida como colagenasa PMNL (MNL-CL), es una enzima que escinde el colágeno que se encuentra en el tejido conectivo de la mayoría de los mamíferos. En humanos, la proteína MMP-8 está codificada por el gen MMP8. Sus sustratos abarcan colágenos de tipo I, II, III, VII, VIII, X, así como agrecano y gelatina. En particular, MMP-8 puede sufrir activación proteolítica mediante enzimas como estromelisina-1 (MMP-3), estromelisina-2 (MMP-10) y matrilisina-1 (MMP-7).
Características del producto
category
ELISA Kits
reactivity
guinea pig
test range
0.156-10ng/ml
assay type
Sandwich ELISA, Double Antibody
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Tissue homogenates,Other biological fluids
size 1
96T
alias
MMP-8|Matrix Metalloproteinase 8|Collagenase 2|CLG1HNC|neutrophil collagenase|PMNL collagenase|PMNL-CL
storage
2-8 °C for 6 months
or code
MMP-8
uniprot id
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