Guanine Nucleotide Exchange Factor VAV3 (VAV3) Cell ELISA Kit
513.5€ (96 tests)
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935106861
info@markelab.com
name
Guanine Nucleotide Exchange Factor VAV3 (VAV3) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595619
tested applications
ELISA
Description
VAV3 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Guanine Nucleotide Exchange Factor VAV3 (VAV3) |
| Reactivity | Human, Mouse |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UKW4 |
| Gene ID | 10451 |
| OMIM | 605541 |
| Alias | VAV-3 |
| Background | Elisa kits for VAV3 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
VAV3 is a member of the VAV family of guanine nucleotide exchange factors (GEFs) that regulate Rho family GTPases, such as Rac1, RhoA, and Cdc42, to mediate cytoskeletal reorganization, cell migration, and proliferation. VAV3 is expressed in multiple tissues, including the brain, endothelial cells, and immune cells, where it functions in signaling pathways downstream of receptor tyrosine kinases (RTKs), integrins, and immune receptors. It is involved in processes like angiogenesis, neuronal development, and immune cell activation. Dysregulation of VAV3 is associated with cancer, where it promotes tumor cell migration, metastasis, and survival through Rac1 activation and integrin signaling. VAV3 also plays a role in immune responses, including T-cell activation and macrophage function. Knockout studies demonstrate impaired angiogenesis, defective immune cell migration, and reduced tumor metastasis, highlighting its essential role in cytoskeletal regulation, cell signaling, and tumor progression.
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anti- VAV3 antibody
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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