Guanine Nucleotide Exchange Factor VAV3 (VAV3) Antibody (FITC)
169€ (20 µg)
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Name
Guanine Nucleotide Exchange Factor VAV3 (VAV3) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx316661
Description
VAV3 Antibody (FITC) is a Rabbit Polyclonal against VAV3 conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Guanine Nucleotide Exchange Factor VAV3 (VAV3) Immunogen: Recombinant Human Guanine nucleotide exchange factor VAV3 protein (562-674AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKW4 |
| Gene ID | 10451 |
| NCBI Accession | NP_001073343.1, NM_001079874.1, NP_006104.4, NM_006113.4 |
| OMIM | 605541 |
| Alias | VAV-3 |
| Background | Antibody anti-VAV3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
VAV3 is a member of the VAV family of guanine nucleotide exchange factors (GEFs) that regulate Rho family GTPases, such as Rac1, RhoA, and Cdc42, to mediate cytoskeletal reorganization, cell migration, and proliferation. VAV3 is expressed in multiple tissues, including the brain, endothelial cells, and immune cells, where it functions in signaling pathways downstream of receptor tyrosine kinases (RTKs), integrins, and immune receptors. It is involved in processes like angiogenesis, neuronal development, and immune cell activation. Dysregulation of VAV3 is associated with cancer, where it promotes tumor cell migration, metastasis, and survival through Rac1 activation and integrin signaling. VAV3 also plays a role in immune responses, including T-cell activation and macrophage function. Knockout studies demonstrate impaired angiogenesis, defective immune cell migration, and reduced tumor metastasis, highlighting its essential role in cytoskeletal regulation, cell signaling, and tumor progression.
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