Growth Hormone Releasing Hormone Receptor (GHRHR) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Growth Hormone Releasing Hormone Receptor (GHRHR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131084
tested applications
WB, IHC, IF/ICC
Description
GHRHR Antibody is a Rabbit Polyclonal against GHRHR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Growth Hormone Releasing Hormone Receptor (GHRHR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | GHRHR,GRF receptor,GRFR,growth hormone-releasing factor receptor,Ghrfr,IGHD4,IGHD1B |
| Background | Antibody anti-GHRHR |
| Status | RUO |
Descripción
GHRHR is a G protein-coupled receptor that binds growth hormone-releasing hormone (GHRH), regulating the synthesis and secretion of growth hormone (GH) from the anterior pituitary gland. GHRHR is primarily expressed in pituitary somatotroph cells, where its activation stimulates the cAMP/PKA and MAPK signaling pathways, leading to GH gene transcription and release. Growth hormone plays a critical role in growth, metabolism, and tissue repair by promoting the production of insulin-like growth factor-1 (IGF-1) in peripheral tissues. Mutations or dysregulation of GHRHR are associated with growth hormone deficiencies, leading to short stature, delayed growth, and metabolic imbalances. GHRHR has also been implicated in aging, where reduced GH signaling contributes to age-related declines in muscle mass and bone density. Therapeutically, GHRHR agonists are used to stimulate growth hormone production in patients with GH deficiency, while antagonists are being explored for treating acromegaly and certain cancers where GH overproduction contributes to tumor growth. GHRHR is a key target for modulating growth hormone signaling and managing growth and metabolic disorders.
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