Growth Differentiation Factor 15 (GDF15) Antibody
416€ (200 µl)
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935106861
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name
Growth Differentiation Factor 15 (GDF15) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432737
tested applications
P-ELISA, WB, IHC, FCM
Description
GDF15 Antibody is a Goat Polyclonal antibody against GDF15.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Growth Differentiation Factor 15 (GDF15) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 9518 |
| NCBI Accession | NP_004855.2 |
| Alias | HG,PDF,MIC1;,PLAB,MIC-1,NAG-1,PTGFB, GDF-15 |
| Background | Antibody anti-GDF15 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
GDF15, a stress-responsive cytokine, stands as a distinct member within the diverse TGF-β superfamily. Its expression is typically low in most tissues during normal physiological conditions. However, when cardiac myocytes face ischemia or heightened ventricular wall stress, GDF-15 expression intensifies significantly. This cytokine has emerged as a potent prognostic indicator in various diseases, including heart diseases and cancer. Interestingly, it appears to act protectively against cardiac injury, attributed to its antihypertrophic, antiapoptotic, and anti-inflammatory properties, although the specific receptor through which GDF-15 exerts its effects remains unidentified. Studies have revealed a positive correlation between elevated GDF-15 levels and factors such as LV mass, IL-6, and MMP-9 levels in patients with heart failure (HF)
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