GRB2 Related Adaptor Protein (GRAP) Antibody
442€ (200 µl)
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935106861
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name
GRB2 Related Adaptor Protein (GRAP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432144
tested applications
P-ELISA, WB
Description
GRAP Antibody is a Goat Polyclonal antibody against GRAP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: GRB2 Related Adaptor Protein (GRAP) Immunogen: abx269031 - C-Terminus: C-GFFPRSYVQPVHL |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 10750, 71520 |
| NCBI Accession | NP_006604.1 |
| Alias | GRAP, GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114 |
| Background | Antibody anti-GRAP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
GRAP is an adaptor protein similar to GRB2, containing SH2 and SH3 domains that mediate protein-protein interactions between receptor tyrosine kinases and intracellular signaling molecules. It is primarily expressed in hematopoietic and immune cells, where it plays a critical role in T-cell receptor (TCR) and cytokine receptor signaling pathways, including MAPK/ERK, JNK, and calcium mobilization cascades. GRAP functions as a scaffold protein, recruiting signaling molecules like SOS, PLCγ, and SHC to facilitate pathways that regulate cell proliferation, survival, and differentiation. It supports immune cell activation, lymphocyte development, and adaptive immune responses. Dysregulation of GRAP impairs immune signaling, leading to defects in T-cell activation, cytokine production, and immune homeostasis. It is particularly important in balancing immune responses to prevent overactivation or immunodeficiency. Knockout studies emphasize its role in TCR signaling, showing defects in T-cell proliferation and response to antigenic stimulation.
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