GRB2 Related Adaptor Protein 2 (GRAP2) Antibody Pair

Product specifications

Antibody Pairs

GRB2 Related Adaptor Protein 2 (GRAP2)

Human

Detection Antibody Biotinilated

Sandwich

Dilute the Capture Antibody 125-fold with Coating Buffer.  Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent.  Optimal dilutions/concentrations should be determined by the end user.

5 × 96 tests

10 × 96 tests

Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody)
Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user.

ELISA

The Capture and Detection Antibody both contain 0.1% sodium azide.

Please enquire.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adaptor protein 2, GRB2 related adaptor protein 2

Antibody Pair for GRAP2

RUO

This antibody pair contains ( 5 x 96 det):    Detection:  50 µg  Capture:  200 µg  Standard:  2 µg
This product is for research use only.

Descripción

GRAP2, also known as GADS (GRB2-related adaptor downstream of SHC), is a hematopoietic-specific adaptor protein that serves as a key mediator in immune cell activation. It contains SH2 and SH3 domains, enabling interactions with critical proteins like LAT (linker for activation of T cells), SLP-76, and SOS to form multiprotein complexes (signalosomes). These complexes activate downstream signaling pathways, including NF-κB, MAPK/ERK, and actin cytoskeletal rearrangements required for immune synapse formation. GRAP2 is essential for T-cell receptor (TCR) and B-cell receptor (BCR) signaling, supporting processes like lymphocyte proliferation, antigen receptor-mediated activation, and cytokine production. GRAP2 is required for immune cell polarization, adhesion, and migration, ensuring effective adaptive immune responses. Dysregulation contributes to immune deficiencies, autoimmune diseases, and hematopoietic disorders, affecting lymphocyte development and function. Knockout studies reveal impaired T-cell development, antigen signaling defects, and reduced cytokine responses, highlighting its critical role in adaptive immunity and lymphocyte signaling.

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