GRB2 Related Adaptor Protein 2 (GRAP2) Antibody
312€ (0.1 mg)
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Name
GRB2 Related Adaptor Protein 2 (GRAP2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139988
Tested Applications
WB, FCM, IP
Description
GRAP2 Antibody is a Mouse Monoclonal against GRAP2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: GRB2 Related Adaptor Protein 2 (GRAP2) Immunogen: GST-fusion Human GRAP2/GADS protein. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | FCM: 2-6 μg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | P790 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | O75791 |
| Gene ID | 9402 |
| Alias | GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adaptor protein 2, GRB2 related adaptor protein 2 |
| Background | Antibody anti-GRAP2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GRAP2, also known as GADS (GRB2-related adaptor downstream of SHC), is a hematopoietic-specific adaptor protein that serves as a key mediator in immune cell activation. It contains SH2 and SH3 domains, enabling interactions with critical proteins like LAT (linker for activation of T cells), SLP-76, and SOS to form multiprotein complexes (signalosomes). These complexes activate downstream signaling pathways, including NF-κB, MAPK/ERK, and actin cytoskeletal rearrangements required for immune synapse formation. GRAP2 is essential for T-cell receptor (TCR) and B-cell receptor (BCR) signaling, supporting processes like lymphocyte proliferation, antigen receptor-mediated activation, and cytokine production. GRAP2 is required for immune cell polarization, adhesion, and migration, ensuring effective adaptive immune responses. Dysregulation contributes to immune deficiencies, autoimmune diseases, and hematopoietic disorders, affecting lymphocyte development and function. Knockout studies reveal impaired T-cell development, antigen signaling defects, and reduced cytokine responses, highlighting its critical role in adaptive immunity and lymphocyte signaling.
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