GRB2-Associated-Binding Protein 2 (GAB2) Antibody
292.5€ (80 µl)
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Name
GRB2-Associated-Binding Protein 2 (GAB2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx033055
Tested Applications
ELISA, WB, FCM
Description
GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: GRB2-Associated-Binding Protein 2 (GAB2) Immunogen: KLH-conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human GAB2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 74.5 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UQC2 |
| Alias | KIAA0571, Pp100,GRB2-Associated Binder |
| Background | Antibody anti-GAB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GAB2 is a key adaptor protein that links receptor tyrosine kinases and cytokine receptors to intracellular signaling cascades, including PI3K/Akt, MAPK, and STAT pathways. It is predominantly expressed in hematopoietic cells, where it regulates immune cell activation, differentiation, and cytokine signaling. GAB2 interacts with GRB2, SHP2, and PI3K to modulate immune responses, hematopoiesis, and mast cell degranulation. Dysregulation of GAB2 is associated with inflammatory diseases, autoimmunity, and cancer, particularly leukemia, breast cancer, and melanoma, where it enhances cell proliferation, survival, and migration. Knockout studies highlight defects in immune cell activation, mast cell responses, and hematopoietic development, demonstrating its importance in immune regulation.
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