Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha (Csf2ra) Antibody (PE)
429€ (100 tests)
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935106861
info@markelab.com
name
Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha (Csf2ra) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx139383
tested applications
FCM
Description
CD116 Antibody is a Mouse Monoclonal against CD116.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha (Csf2ra) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 Kappa |
| Clone ID | S274 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P15509 |
| Gene ID | 1438 |
| Alias | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha,GMR,CD116,CSF2R,SMDP4,CDw116,CSF2RX,CSF2RY,GMCSFR,CSF2RAX,CSF2RAY,alphaGMR,GMR-alpha,GMCSFR-alpha,GM-CSF-R-alpha |
| Background | Antibody anti-CSF2RA |
| Status | RUO |
Descripción
Colony stimulating factor 2 receptor subunit alpha (CSF2RA) is a protein that serves as part of the receptor complex for granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine critical for the growth, differentiation, and function of granulocytes and macrophages. This receptor subunit is primarily expressed on the surface of myeloid lineage cells, including neutrophils, monocytes, and macrophages, as well as on some non-hematopoietic tissues. CSF2RA forms a heterodimer with the common beta chain (CSF2RB) to mediate the signaling of GM-CSF, which activates pathways such as JAK/STAT, MAPK, and PI3K, driving cell proliferation, survival, and activation. Dysregulation of CSF2RA signaling has been associated with conditions like inflammatory diseases, including rheumatoid arthritis and asthma, as well as hematological malignancies such as leukemia. Mutations or deletions in the CSF2RA gene can impair immune responses and are linked to congenital disorders like surfactant metabolism dysfunction in the lung. Given its role in immune modulation, CSF2RA is being explored as a therapeutic target in cancer immunotherapy and inflammatory conditions, aiming to modulate the activity of GM-CSF and its downstream effects. Understanding its molecular mechanisms continues to provide insights into immune regulation and potential clinical interventions.
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