Gonadotropin Releasing Hormone Receptor (GNRHR) Antibody
377€ (100 µg)
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Name
Gonadotropin Releasing Hormone Receptor (GNRHR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx233555
Tested Applications
ELISA, WB, IHC, FCM, IP
Description
GNRHR Antibody is a Rabbit Polyclonal against GNRHR.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Gonadotropin Releasing Hormone Receptor (GNRHR) Immunogen: gonadotropin-releasing hormone receptor |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 38 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30968 |
| Alias | GNRHR,luteinizing hormone-releasing hormone (LHRH) receptor,GNRHR1,LHRH receptor,Type I GnRHR,gnRH receptor,GnRH-R,GnRH I receptor,GnRHR,luliberin receptor ,LHRHR, GRHR, HH7, LHRHR,GnRH1 receptor |
| Background | Antibody anti-GNRHR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GNRHR is a G protein-coupled receptor (GPCR) expressed primarily in the anterior pituitary gland, where it binds gonadotropin-releasing hormone (GnRH). Upon activation, GNRHR stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate gonadal function, steroidogenesis, and gametogenesis. GNRHR signaling occurs through Gq/11 proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating protein kinase C (PKC). It plays a central role in reproductive physiology, controlling the menstrual cycle in females and testosterone production in males. Mutations in GNRHR are linked to disorders such as hypogonadotropic hypogonadism, characterized by delayed puberty and infertility. GNRHR is also expressed in extra-pituitary tissues and certain cancers, such as breast, prostate, and ovarian cancers, where it regulates cell proliferation and survival. Therapeutically, GnRH agonists and antagonists are used to treat hormone-dependent conditions, including infertility, endometriosis, and cancers. GNRHR remains a critical target in reproductive medicine and oncology.
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