GM-CSF Receptor alpha Protein
234€ (5 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
GM-CSF Receptor alpha Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx260768
Tested Applications
SDS-PAGE
Description
GM-CSF Receptor Alpha Protein is a recombinant cytokine.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | CSF2RA |
| Assay Type | Activity: Not tested |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P15509 |
| Alias | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha,GMR,CD116,CSF2R,SMDP4,CDw116,CSF2RX,CSF2RY,GMCSFR,CSF2RAX,CSF2RAY,alphaGMR,GMR-alpha,GMCSFR-alpha,GM-CSF-R-alpha |
| Background | Protein CSF2RA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Colony stimulating factor 2 receptor subunit alpha (CSF2RA) is a protein that serves as part of the receptor complex for granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine critical for the growth, differentiation, and function of granulocytes and macrophages. This receptor subunit is primarily expressed on the surface of myeloid lineage cells, including neutrophils, monocytes, and macrophages, as well as on some non-hematopoietic tissues. CSF2RA forms a heterodimer with the common beta chain (CSF2RB) to mediate the signaling of GM-CSF, which activates pathways such as JAK/STAT, MAPK, and PI3K, driving cell proliferation, survival, and activation. Dysregulation of CSF2RA signaling has been associated with conditions like inflammatory diseases, including rheumatoid arthritis and asthma, as well as hematological malignancies such as leukemia. Mutations or deletions in the CSF2RA gene can impair immune responses and are linked to congenital disorders like surfactant metabolism dysfunction in the lung. Given its role in immune modulation, CSF2RA is being explored as a therapeutic target in cancer immunotherapy and inflammatory conditions, aiming to modulate the activity of GM-CSF and its downstream effects. Understanding its molecular mechanisms continues to provide insights into immune regulation and potential clinical interventions.
Productos relacionados
Colony Stimulating Factor 2 Receptor Alpha (CSF2RA) Antibody
CSF2RA Antibody is a Rabbit Polyclonal antibody against CSF2RA. The protein encoded by this gene is the alpha subunit of…
Ver producto
Colony Stimulating Factor 2 Receptor Alpha (CSF2RA) Antibody
CSF2RA Antibody is a Rabbit Polyclonal antibody against CSF2RA. The protein encoded by this gene is the alpha subunit of…
Ver producto
Colony Stimulating Factor 2 Receptor Alpha (CSF2RA) Antibody
Rabbit polyclonal antibody against CSF2RA protein. Immunogen region is Internal.…
Ver producto