Glycoprotein Ib Beta Polypeptide, Platelet (GP1BB) Antibody
312€ (60 µl)
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935106861
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name
Glycoprotein Ib Beta Polypeptide, Platelet (GP1BB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx136023
tested applications
WB
Description
GP1BB Antibody is a Rabbit Polyclonal against GP1BB.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glycoprotein Ib Beta Polypeptide, Platelet (GP1BB) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P13224 |
| Gene ID | 2812 |
| NCBI Accession | NP_000398.1 |
| Alias | BS,CD42C,GPIBB,BDPLT1,GPIbbeta,Platelet glycoprotein Ib beta chain, GP-Ib beta,GPIb-beta,GPIbB,Antigen CD42b-beta,CD42c |
| Background | Antibody anti-GP1BB |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Glycoprotein Ib platelet subunit beta (GP1BB) is a critical component of the Glycoprotein Ib-IX-V (GPIb-IX-V) complex, a receptor complex expressed on the surface of platelets. This receptor is central to platelet adhesion under conditions of high shear stress and plays a pivotal role in the initiation of platelet plug formation, particularly in arterial circulation where rapid blood flow is present. The GPIb-IX-V complex interacts with von Willebrand factor (vWF) to mediate the tethering of platelets to the site of vascular injury, marking the beginning of the hemostatic process that leads to clot formation and wound healing. GP1BB is the beta subunit of the GPIb-IX-V complex, and it is necessary for proper assembly and function of the entire receptor complex. The GP1BB protein contributes to the stability of the receptor on the platelet surface and forms part of the binding interface with other components of the GPIb-IX-V complex, including GP1BA, GPIX, and GPV.
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